EDAR and neoplasm: In addition, localization of Dl to the plasma membrane rather than to the cytoplasm was predominantly observed in βint-ν2 flies, which was similar to that in the ISC-like tumour in the neuralized mutant where symmetric division occurred exclusively by inactivating Dl/N signalling (Figure 4B and 4B’ arrows in insets compared with 4A and 4A’ arrows in insets) [16].