Combined mAb treatment significantly increased the expression of T-bet and IFN-γ genes indicative of Th1-type immune response while attenuating the expression of IL-10 genes indicative of Th2-type immune response, and this expression pattern was also confirmed by ELISA at the protein level, suggesting the shaping of tumor-destructive Th1-type immune response locally by 2 mAb treatment. This evidence concerns the gene IFNG and neoplasm.