With respect to NOD2 rs2066844, rs2066845 and rs2066847 polymorphisms, the dominant effect models of the three polymorphisms all indicated significantly increased cancer risk (OR for rs2066844 = 1.32; OR for rs2066845 = 1.32; OR for rs2066847 = 1.23) (Table 2). Here, NOD2 is linked to cancer.