A common variant within the GCKR gene, which encodes GKRP, is reproducibly associated with inverse risk of type 2 diabetes (T2D) and lipid traits such as plasma cholesterol and triglyceride levels, and rare coding variants within GCKR show association with hypertriglyceridemia and diabetes-related phenotypes [11]–[13]. The gene discussed is GCKR; the disease is type 2 diabetes mellitus.