TNF and migraine disorder: Other previously noted usage patterns include the use of the anti-seizure medications such as pregabalin and lamotrigine for migraines [33], [34], and the use of immuno-modulators such as etanercept and adalimumab, two Tumor Necrosis Factor (TNF) inhibitors, for systemic lupus erythematosus (SLE) [35], [36].