ABCC6 and arterial calcification, generalized, of infancy, 1: It is also of interest to note that ABCC6 mutations have been recently demonstrated in patients with generalized arterial calcification of infancy (GACI), a severe vascular mineralization disorder often diagnosed by prenatal ultrasound, with peri- and early postnatal demise in the majority of patients before 6 months of age [17], [18].