In line with the results from previous studies, no significant differences in allele and genotypic frequencies of ABCB1 and ABCG2 variants were observed between MTLE-HS and JME cohorts, thereby, ruling out the role of ABCB1 and ABCG2 variants in determining the AED-resistance in epilepsy. The gene discussed is ABCB1; the disease is epilepsy.