For instance, DSG1 suppresses the epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) pathway during epidermal differentiation [2], DSC3 functions as a tumor suppressor by inhibiting the EGFR/extracellular signal-regulated kinase (ERK) signaling in human lung cancer [3], DSP acts as a tumor suppressor by inhibiting the wingless-type mouse mammary tumor virus integration site family (Wnt) signaling pathway in human lung cancer [4] and JUP indirectly inhibits Rous sarcoma oncogene (Src) kinase in prostate cancer [5]. The gene discussed is DSP; the disease is lung cancer.