In contrast to the normal group, the oxidative stress related proteins Cytochrome P450 17A1(CYP27A1), Fructose-bisphosphate aldolase B (ALDOB), Stress-70 protein (GRP75), Ornithine carbamoyltransferase (OTC) and so on were decreased in the HCC group. The gene discussed is CYP17A1; the disease is hepatocellular carcinoma.