On the other hand, the functional SNPs of the other three activating FcγRs (FcγRIIIA, FcγRIIIB, and FcγRIIC) were not associated with asthma, BHR, and atopy, suggesting that functions of the restrictively expressed activating FcγRs (FcγRIIIA, FcγRIIIB, and FcγRIIC) may not play prevailing roles in the development of allergy. This evidence concerns the gene FCGR3A and allergic disease.