Regarding ALS and other neuromuscular diseases, support for a BMPs' relevance is continuing to be revealed by genetic studies in Drosophila, including that a homologue of BMPs and homologues of BMP receptors are each required for normal NMJ development in flies [1], [4], [46], [47], but suggestions of such functions for BMP pathway components rarely extend to vertebrates. The gene discussed is CLN5; the disease is neuromuscular disease.