Previously, we demonstrated that a product of uterine sensitization-associated gene-1 (USAG-1), a novel Bmp antagonist expressed in the distal tubules of the kidney, plays a critical role in modulating the renoprotective action of Bmp, and that inhibition of USAG-1 is a promising potential novel treatment for various renal diseases[23], [24], [26]. The gene discussed is SOSTDC1; the disease is kidney disorder.