One of our previous studies have demonstrated that the IL-23R rs10889677A>C SNP may alter IL-23R expression by modifying miR-let-7f binding to the 3′UTR of the IL-23R gene [13], thereby influence the transcription of IL-23R in vivo and in vitro in breast, lung and nasopharyngeal cancer. The gene discussed is IL23R; the disease is nasopharyngeal carcinoma.