Using the colitis-associated cancer model, Maeda et al[30] showed that the incidence and growth of tumor could be decreased by neutralizing anti-HMGB1 antibody, which inhibited the expression of HMGB1.Our contingency table analysis, however, showed that HMGB1 expression does not correlate with any of the clinicopathological parameters analyzed in this study, but AFP. Here, HMGB1 is linked to neoplasm.