In the Clinical and Functional Translation of CFTR database (CFTR2; www.cftr2.org), c.2052_2053insA has been reported as causing pancreatic insufficiency (PI); here, most of the patients were PI but some were pancreatic sufficient (PS); the same was observed for patients carrying c.3468+2_3468+3insT. The gene discussed is CFTR; the disease is exocrine pancreatic insufficiency.