Complement factor H (CFH) genotypes have been identified as major contributors to the risk of developing AMD [51], [52] and we found that the AMD patients with the homozygous CFH high risk genotype had on average lower MPOD (0.43±0.1 D.U.)compared to the low risk genotypes (0.47±0.1 D.U) (data not shown, p = 0.2). This evidence concerns the gene CFH and age-related macular degeneration.