In contrast, CCR5 chemokines Macrophage Inflammatory Protein-1α (MIP-1α), MIP-1β, Monocyte chemotactic protein (MCP)-2 and RANTES naturally restrict HIV-1 infection by masking virus binding sites and promoting CCR5 cell surface down-modulation [12], [13]. The gene discussed is CCR5; the disease is HIV-1 infection.