Specific TRA2B-related splicing processes have been implicated in human diseases like spinal muscular atrophy (splicing of SMN) [22], [23], [24] and in tauopathies like Alzheimer’s disease and FTDP-17 (splicing of MAPT) [25], [26], [27], [28]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.