IL6 and Alzheimer disease: Meanwhile, increasing evidence indicates that miR146a plays a role in stimulating the inflammation response in the brains of AD patients [12]–[14], and our results also confirm that the AA genotype could increased the mature level of miR146a and elevated the level of proinflammatory cytokines IL-1β and IL-6, so we speculate that the change in the expression level of miR146a by the rs57095329 polymorphism may in turn regulated the inflammation response in the brains of AD patients, which could further contribute to the AD susceptibility.