COL4A5 and leukemia: Figure 7 demonstrates that Ly6a/Sca-1 high leukemia cells exhibited significantly greater capacity to invade and migrate through the Matrigel matrix. We observed this in all four leukemia models: the C1498 leukemia (Figure 7A), the NSTY leukemia clones (Figure 7B), the NSTY knockdown (Figure 7B) and the ASLN knockdown (Figure 7C).