CMTM3 and Familial prostate cancer: Compared with the high expression of CMTM3 in normal human testis tissues, the expression of CMTM3 was silenced in a seminoma cell line (NCCIT) and down-regulated or silenced in 2 of 4 prostate cancer cell lines, 2 of 3 renal cancer cell lines and in none of the bladder tumor cell lines studied (Figure 1C).