Compared with the high expression of CMTM3 in normal human testis tissues, the expression of CMTM3 was silenced in a seminoma cell line (NCCIT) and down-regulated or silenced in 2 of 4 prostate cancer cell lines, 2 of 3 renal cancer cell lines and in none of the bladder tumor cell lines studied (Figure 1C). The gene discussed is CMTM3; the disease is prostate carcinoma.