Of the targets predicted here, NFAT5, a member of the nuclear factors of activated T cells (NFAT) family of transcription factors and a component of the mitogen-activated protein kinase (MAPK) pathway, is of particular interest as it has previously been linked with TB; the innate immune response to M.tb infection strongly induces NFAT5 gene and protein expression [16]. This evidence concerns the gene WNK2 and tuberculosis.