Taken the above together with the increased frequency of variant genotypes observed in AML patients with t(8;21), -5/del(5q), -7/del(7q), +8 and +21, it could be suggested that CYP2B6 enzyme deficiency may affect individual’s vulnerability to hematotoxic exposure to leukemogens and may contribute to an increased risk of AML carrying aberrations of chromosomes 5, 7, 8 and/or 21 and t(8;21). Here, CYP2B6 is linked to acute myeloid leukemia.