CYP2B6 and acute myeloid leukemia: In the present study, in order to evaluate the potential impact of the G516T CYP2B6 polymorphism in AML susceptibility, we studied the distribution of the G516T CYP2B6 genotypes and allele frequencies in a large cohort of Greek patients (n = 619) with de novo or secondary AML and in healthy individuals (n = 430).