CRTC1 and diffuse large B-cell lymphoma: Using a broader panel of 9 DLBCL lines, we found that 200 nM MLN0128 effectively inhibited phosphorylation of both TORC1 (phospho-S6, phospho-4EBP1) and TORC2 (phospho-AKT-S473) outputs in all the cell lines tested (Fig. 2).