SLC29A1 and diffuse idiopathic skeletal hyperostosis: Furthermore, the loss of ENT1 leads to progressive ectopic mineralization of the upper thoracic and cervical spinal cord resembling diffuse idiopathic skeletal hyperostosis (DISH) in humans [18], however, the effect of ENT1 deletion on bone density in the lower portion of the spinal column (lower thoracic and lumbar vertebrae) and femur remained unknown.