Based on our findings that CORM-2 increases TTP levels, and in turn, TTP mediates the anti-inflammatory effect of CORM-2 in macrophages and TTP deficiency exacerbates DSS-induced colitis, we hypothesized that exogenous CO and CO-RM may protect mice from DSS-induced colitis through a TTP–dependent mechanism. This evidence concerns the gene ZFP36 and colitis.