Recently, further data were published indicating that a knockout of Agxt2 in mice is associated with elevation of ADMA and SDMA plasma concentrations and that the AGXT2 single nucleotide polymorphism (SNP) rs37369 (c.418G>A, p.Val140Ile) is associated with hypertension in humans [14]. The gene discussed is AGXT2; the disease is hypertensive disorder.