Our previous B6-apoE x 129-apoE cross showed a suggestive QTL at the same location (peak: 154 Mb, CI: 112 - 164 Mb, LOD: 3.8) where B6 allele confers atherosclerosis susceptibility over 129 allele [15], suggesting that the locus is likely shared in DBA and B6. Here, APOE is linked to atherosclerosis.