The 155 - 157 Mb interval is syntenic with Chr1q25, where an intron SNP marker in RGS8 is associated with cardiovascular disease (8.9) and SNPs near and within the CACNA1E gene are associated with HDL cholesterol levels (9.5), echocardiography (5.2) and blood pressures (4.9). This evidence concerns the gene RGS8 and cardiovascular disorder.