In the current study, we considered five key signaling molecules namely phosphatidyl inositol-4,5-bisphosphate 3-kinase (PI3K), AKT (also known as PKB, protein kinase B), anti-apoptotic protein B cell lymphoma-2 (Bcl-2), NF-κB, and Stat3 which play important role in cancer development and progression. This evidence concerns the gene STAT3 and cancer.