AKT1 and cancer: The inhibitory effect of PL was shown by alterations of various signaling pathways which play a crucial role in cancer cell proliferation, survival, invasion, and metastasis [14], [16], [18], [20]–[22] through suppression of major signaling molecules such as nuclear factor-kappaB (NF-κB) [23], AKT/mTOR [13], and signal transducer and activator of transcription 3 (Stat3) [24].