Here, we show that four out of five SCLC cell lines reversibly develop a neuron-like phenotype in the presence of the unspecific PKC inhibitor staurosporine (SSP) when cultivated on an ECM substratum, such as fibronectin (FIB), LAM, and thrombospondin (THR) or on RGDS-peptides. Here, FN1 is linked to small cell lung carcinoma.