As such, in the current series of studies, we focused on the mechanobiology of breast cancer cell motility and have shown that, in addition to its role in tumor cell invasion, MYOF governs undirected, single cell migration reminiscent of mesenchymal motility and that depletion of MYOF results in collective cell migration reminiscent of epithelial sheet–like migration [5], [20], [41]–[44]. This evidence concerns the gene MYOF and breast cancer.