In the present study, five single nucleotide polymorphisms (SNPs) in IGF-I (rs6214, rs6218, rs35767, rs5742612, rs5742714) and four SNPs in IGFBP-3 (rs2132572, rs2854744, rs2854746, rs9282734) were selected and their association with PCa risk in the Chinese population was evaluated. The gene discussed is IGF1; the disease is posterior cortical atrophy.