Substantial epidemiologic and experimental evidence, both in vivo and in vitro, have implicated the IGF pathway as playing a role in prostate carcinogenesis and progression, including cellular metabolism, differentiation, proliferation, transformation, anti-apoptosis, angiogenesis, bone metastases and androgen-independent progression [7], [20], [21]. The gene discussed is IGF1; the disease is urogenital neoplasm.