ERBB2 and breast neoplasm: Surprisingly, miR-100 was found to be downregulated in all subtypes of human breast tumors, including luminal A (P = 1×10−11), luminal B (P = 0.008), basal-like (P = 0.006) and HER2 (P = 0.001) subtypes, compared with paired normal breast tissues (Figure 2A).