These included Endou (Pp11), a placental poly-U endonuclease over-expressed in ovarian adenocarcinomas [34], Xrra1, which has been shown to modulate the response to X-ray irradiation [35], and Ttc28 (Tprbk), encoding a large tetratricopeptide domain protein that is regulated by p53, complexes with BRCA1 and suppresses the growth of Ras-transformed cells [36]. The gene discussed is XRRA1; the disease is ovarian adenocarcinoma.