Evidence that these are also under oncogenic selection is provided by the fact that 17 of the 20 most frequent targets have been observed in end-stage lymphomas (Table S6) and by the fact that a significant subset have annotation suggestive of tumour suppressor or oncogene function (Ikzf3, Mad1l1, Als2, Ppp1r16b, Prex1, Ttc28 and Ptprc). This evidence concerns the gene MAD1L1 and neoplasm.