However, there was also a marked loss of selection for some major targets recorded by Kool et al. including Gfi1 and Notch1. It appears that the combination of MYC and Runx2 in this context also renders these insertions redundant, which is intriguing as insertions at Gfi1 have been shown to be positively selected in some CD2-Runx2 lymphomas [18]. This evidence concerns the gene NOTCH1 and lymphoma.