We therefore suggest that de-repression of Myc may be one of the consequences of Ikzf1 targeting that leads to its co-selection with Runx2. It would interesting in this regard to test whether lymphomas of Runx2 transgenic mice with reduced Ikzf1 function [68] would show reduced RIM targeting of both Myc family genes and Ikzf1. The gene discussed is IKZF1; the disease is lymphoma.