The most frequently targeted CIS targets displaying strong evidence of enhancer mode activation included Otx2, a homeobox transcription factor which plays a major oncogenic role in medulloblastoma [32] but has not previously been observed in haematopoietic cancers and Myo16, an atypical nuclear myosin with links to survival, cell cycle progression and PI3K signalling [33]. The gene discussed is MYH14; the disease is in situ carcinoma.