SLC45A2 and malaria: The only CEU-YRI FST values that are more extreme all involve well-known examples of local geographical adaptation in humans: the SLC24A5 and SLC45A2 genes (with an FST of 0.9826 and 0.9765, respectively), which have been associated with light skin pigmentation in Europeans; and the DUFFY gene (with an FST of 0.9765), which provides resistance to the malaria pathogen Plasmodium vivax.