EIF2AK2 and leukemia: Indeed, ISG products such as double-stranded RNA-activated protein kinase (PKR) [8], myxovirus resistance protein (Mx) [9], p53 [10], ISG20 [11], Ifit2/ISG54 [12] and ProMyelocytic Leukemia (PML) [13], [14] have been reported to confer resistance to VSV infection.