Patients with autosomal dominant or sporadic deficiency in monocytes, DCs, and NK cells (termed MonoMAC syndrome) due to mutations in the transcription factor GATA2 are prone to disseminated nontuberculous mycobacterial infections (incidence ∼80%), invasive fungal infections (incidence ∼30%), primarily histoplasmosis but also aspergillosis, and to viral infections (e.g. human papilloma virus; incidence ∼80%). This evidence concerns the gene GATA2 and fungal infectious disease.