One particular interesting prediction of DCQ is heterogeneity in quantity changes in DCs [Fig 3, bottom right panel; Supplementary Table S5; (Geissmann et al, 2010)]: Two subtypes of plasmacytoid dendritic cells (pDCs) undergo robust early increase during infection (CD8+ and CD8− pDCs); the quantity of one conventional/classical DC (cDC) is slightly increased and then reduced (CD103+ CD11b−); and one cDC subset (CD103− CD11b+) manifests a late increase in cell quantity. Here, CD8A is linked to infection.