HSPB7 and renal cell carcinoma: To investigate whether the methylation status of the HSPB7 gene could affect HSPB7 expression in RCCs, 5 RCC cell lines, Caki-1, Caki-2, ACHN, 786-O and A498 were treated with a demethylating agent 5-Aza-dC, and then the expression levels of HSPB7 were analyzed by qPCR, western blot and IHC analysis.