The expression of HSPB7 was significantly induced in p53-dependent manner that was clearly demonstrated by two experiments, i) that introduction of adeno-p53 in p53-negative cancer cells showed strong induction of HSPB7 and ii) that DNA-damage-dependent introduction of HSPB7 was observed in HCT116 cells with wild-type p53, but not in those lacking p53. Here, HSPB7 is linked to cancer.