Bisulfite sequencing of a genomic region of HSPB7 detected DNA hypermethylation of some segments of HSPB7 in RCC cells and concordantly 5-aza-2′-deoxycytidine (5-Aza-dC) treatment of cancer cells restored HSPB7 expression significantly. Here, HSPB7 is linked to renal cell carcinoma.