We found that HSPB7 mRNA expression were restored in all the 5 RCC cell lines by the treatment with 5-Aza-dC (Fig. 3A), and the HSPB7 protein expression could also be detected in two cell lines, 786-O and A498, in which mRNA expression was most highly induced (Fig. 3B), indicating suppression of HSPB7 in RCC was caused probably by DNA hypermethylation. Here, HSPB7 is linked to renal cell carcinoma.