HNF1A and chromophobe renal cell carcinoma: After identifying a 50-year-old patient with ovarian and chromophobe renal cell carcinoma, Rebouissou et al. found biallelic HNF1ß inactivation (by the combination of an HNF1ß germline mutation and a somatic gene deletion) in two of 12 chromophobe renal cell carcinomas [52].