Notably, the closely related homeodomain-containing transcription factor HNF1α, to which HNF1ß binds DNA as homo-dimers or hetero-dimers to activate transcription of targeted genes, exhibits a well-established tumor suppressor function in hepatocarcinogenesis and may also participate in the development of other tumors, such as colorectal and clear cell renal carcinomas. The gene discussed is HNF1A; the disease is neoplasm.