A subset of these genes (4.9%) showed demethylation and reexpression in all three cancer types including PYCARD, B3GALT4, CARD9, EID3, TSPYL5, IFF01, FERMT3, and AC5. The highest percentages of these demethylation and reexpression events were again seen in immune genes; 26%, of the 162 genes were categorized as immune related (Fig. S3b,c). This evidence concerns the gene TSPYL5 and cancer.