Among the many phenotypic changes that can occur during CAVD is the upregulated expression of matrix metalloproteinases 1, 3, 9 and 13 (MMP-1, MMP-3, MMP-9 and MMP-13) [18,19], all of which are associated with collagen degradation [20]. This evidence concerns the gene MMP1 and congenital bilateral aplasia of vas deferens from CFTR mutation.