Chou et al., showed an increase in HLA-DRB1*11 in RHD patients in Taiwan [7] but Haydardedeoglu et al. [20], and Guadalupe et al., [9], found HLA-DRB1*11 to be decreased in RHD patients from Turkey and Mexico, respectively. This evidence concerns the gene HLA-DRB1 and rheumatic heart disease.