Growth hormone therapy led to partial catch-up growth in two of the three patients but just prevented further height loss in the third.<h4>Conclusions</h4>The pituitary hypoplasia, growth hormone deficiency and growth retardation associated with 14q22q23 microdeletions are very remarkable, and the latter appears to have an atypical response to growth hormone therapy in some of the cases. The gene discussed is GH1; the disease is hypophysitis.