Thus, we have found that MK-2206 treatment inhibits the Akt-pEzrinT567-XIAP cell survival-signaling axis leading to a caspase-dependent cell death in the IGF1R-dependent CRC cells, in addition to caspase independent cell death accompanying AIF translocation from the mitochondria to the nucleus. The gene discussed is AIFM1; the disease is colorectal carcinoma.