ATG7 and gallbladder carcinoma: Since we showed that blocking of autophagy by genetic (ATG5 siRNA and ATG7 siRNA) or pharmacological (CQ) means induced cell death in GBC cells grown with 5-FU, it’s possible that autophagy plays a protective role in proteasome inhibitor-induced cell death by elimination cytotoxic cellular component, it may be an resistant factor which diminishes therapeutic effect in both sensitivities and resistantance of gallbladder carcinoma.