This indicates that nuclear maspin may be used as a prognostic marker and possibly as a therapeutic agent for cancer treatment using engineered maspin cDNA, for obtaining nuclear location of maspin, as a genetic drug in gene therapy.In order to confirm the potential usefulness of nuclear maspin as a genetic drug we tested its potential negative effect on normal breast tissue using normal epithelial cell line MCF10A. This evidence concerns the gene SERPINB5 and cancer.