Regardless of whether cranial form (Figure 5A) or cranial shape (Figure 5B) is considered, distinction between the Fgfr2+/P253R and Fgfr2+/S252W Apert syndrome mice cranial morphologies is not apparent at E17.5, but the two mutation groups are fairly well-discriminated at P0. This evidence concerns the gene FGFR2 and Apert syndrome.