The most caudal aspect of the palate has been previously identified as a site of localized dysmorphology in Fgfr2+/S252W and Fgfr2+/P253R Apert syndrome mice, as well as a region where the morphological effects and localized cellular processes of the two Fgfr2 mutations can be differentiated [14]. This evidence concerns the gene FGFR2 and Apert syndrome.