In this study, the expression of p-VASP in the NR group was significantly increased compared with the BC group, but markedly decreased and significantly increased in the DHFZT group, which indicated DHFZT can protect intercellular junction of the intestinal epithelial cells, and then maintain normal intestinal mechanical barrier by regulating the expression of ZO-1 protein and VASP phosphorylation. The gene discussed is VASP; the disease is breast cancer.