A significantly earlier requirement of insulin therapy was observed in patients with thyroid disease onset prior to (group 1; 2.5 yrs; Q1 = 0.0, Q3 = 8.25) or within the same year (group 2; 0.0 yrs; Q1 = 0.0, Q3 = 0.75) of diabetes mellitus onset. The gene discussed is INS; the disease is thyroid gland disorder.