INS and diabetes mellitus: With a median value of 8.0 years (Q1 = 3.0, Q3 = 12.0) patients with thyroid disease diagnosed after diabetes mellitus (group 3) required insulin therapy significantly later when compared to patients with thyroid disease diagnosed prior to (group 1; p < 0.001) or within the same year (group 2; p < 0.001) of diabetes onset.